Hear from healthcare professionals, patients, and caregivers as they share their expertise and experience on INCRELEX®
Learn from the IncrelEXPERTS
The IncrelEXPERTS are a network of healthcare professionals, patients, and caregivers committed to sharing their knowledge about INCRELEX, the only treatment option for severe primary IGF-1 deficiency (SPIGFD). Based on real-world experience, you’ll learn how to recognize and diagnose SPIGFD, dose and titrate INCRELEX, and more. Explore these topics by watching the videos below.
Looking to learn more about INCRELEX? Speak with our Nurse Specialist Team.
Hypersensitivity to mecasermin (rhIGF-1), any of the inactive ingredients in INCRELEX®, or who have experienced a severe hypersensitivity to INCRELEX®. Allergic reactions have been reported, including anaphylaxis requiring hospitalization.
Malignant Neoplasia in pediatric patients with malignant neoplasia or a history of malignancy.
Warnings and Precautions
Hypoglycemia: INCRELEX® should be administered 20 minutes before or after a meal or snack and should not be administered when the meal or snack is omitted. Glucose monitoring and INCRELEX® dose titration are recommended until a well-tolerated dose is established and as medically indicated.
Intracranial Hypertension: Funduscopic examination is recommended at the initiation of and periodically during the course of therapy.
Lymphoid Tissue Hypertrophy: Patients should have periodic examinations to rule out potential complications.
Slipped Capital Femoral Epiphysis: Carefully evaluate any pediatric patient with the onset of a limp or hip/knee pain during INCRELEX® therapy.
Progression of Scoliosis: Patients with a history of scoliosis, treated with INCRELEX®, should be monitored.
Malignant Neoplasia: There have been postmarketing reports of malignant neoplasia in pediatric patients who received treatment with INCRELEX®. The tumors were observed more frequently in patients who received INCRELEX® at higher than recommended doses or at doses that produced serum IGF-1 levels above the normal reference ranges for age and sex. Monitor all patients receiving INCRELEX® carefully for development of neoplasms. If malignant neoplasia develops, discontinue INCRELEX® treatment.
Risk of Serious Adverse Reactions in Infants due to Benzyl Alcohol Preserved Solution: Serious and fatal adverse reactions including “gasping syndrome” can occur in neonates and infants treated with benzyl alcohol-preserved drugs. Use of INCRELEX® in infants is not recommended.
Common adverse reactions include hypoglycemia, local and systemic hypersensitivity, and tonsillar hypertrophy.
INCRELEX® (mecasermin) is indicated for the treatment of growth failure in pediatric patients aged 2 years and older with severe primary IGF-1 deficiency* (IGFD), or with hormone (GH) gene deletion who have developed neutralizing antibodies to GH.1
Limitations of use: INCRELEX® is not a substitute to GH for approved GH indications. INCRELEX® is not indicated for use in patients with secondary forms of IGFD, such as GH deficiency, malnutrition, hypothyroidism, or chronic treatment with pharmacologic doses of anti-inflammatory steroids.1
*Severe primary IGF-1 deficiency (IGFD) is defined by height standard deviation score ≤ -3.0 and basal IGF-1 standard deviation score ≤ -3.0 and normal or elevated GH.
NOTE: You are about to leave an Ipsen Biopharmaceuticals, Inc., website. This link is provided as a service to our website visitors. It will take you to another site maintained by a third party who is solely responsible for its content.
NOTE: You are about to leave an Ipsen Biopharmaceuticals, Inc., website. This link is provided as a service to our website visitors. It will take you to another site maintained by Ipsen Biopharmaceuticals, Inc.